Top 8 Benadryl Competitors & Alternatives in 2026

Updated on 12/24/2025

Find more companies/brands/products like Benadryl. We've shortlisted leading alternatives and mapped their strengths, pricing, and go-to-market focus.

Benadryl

Best for consumers

Est. 1946 • 1k+ employees • Private

Benadryl is a consumer healthcare brand of over-the-counter antihistamine and anti-itch medicines, primarily containing diphenhydramine in the U.S., used to relieve allergy and itch symptoms and owned by Kenvue.

Competitors

#1

Zyrtec

Best for consumers
Est. 1987 • 1k+ employees • Private

Zyrtec is an over-the-counter allergy medicine brand of cetirizine-based antihistamine products for adults and children, owned by consumer health company Kenvue.
#2

Claritin

Best for consumers
Est. 1993 • 1k+ employees • Private

Claritin is a global over-the-counter allergy medicine brand of loratadine-based products owned and marketed by Bayer that provide non-drowsy 24-hour relief from indoor and outdoor allergy symptoms.
#3

Allegra

Best for consumers
Est. 1996 • 201-1k employees • Private

An over-the-counter antihistamine brand based on fexofenadine that provides non-drowsy indoor and outdoor allergy and hives relief.
#4

Xyzal

Best for consumers
Est. 2001 • 1k+ employees • Private

Xyzal is an over-the-counter allergy relief medicine brand based on the antihistamine levocetirizine that provides 24-hour indoor and outdoor allergy symptom relief for adults and children.

Starts at $7.97 / 10 tablets (5 mg each)
ChampSignal

Best for SMBs
Est. 2025 • 1 employee • Private

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Starts at $39 / month

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#5

Cortizone-10

Best for consumers
Est. 1992 • 201-1k employees • Private

Cortizone-10 is a U.S. over-the-counter brand of maximum-strength hydrocortisone topical itch-relief products (creams, lotions, gels, sprays, ointments, and lotions) launched in 1992 and now marketed under Chattem/Opella Healthcare Group, used by consumers to relieve itch and inflammation from conditions such as eczema, psoriasis, insect bites, poison ivy, and other rashes, with entry-level 1 oz creams typically retailing around $5–6 per tube at major U.S. retailers.

Starts at $5.48 / tube
#6

Flonase

Best for consumers
Est. 1994 • 1k+ employees • Private

Flonase is an over-the-counter allergy-relief brand of intranasal corticosteroid sprays and related products that provide 24-hour multi-symptom relief from seasonal and perennial allergies, marketed by Haleon.

Starts at $17.48 / bottle
#7

Nasacort

Best for consumers
Est. 2014 • 201-1k employees • Private

Nasacort is an over-the-counter intranasal corticosteroid (triamcinolone acetonide) nasal spray brand that provides 24-hour relief of nasal allergy symptoms such as congestion, sneezing, and runny or itchy nose in adults and children 2 years and older.

Starts at $13.96 / 0.37 fl oz bottle (60 sprays) / other
#8

GoodSense

Best for consumers
Est. 2010 • 1k+ employees • Private

GoodSense is a consumer over-the-counter medicines brand offering affordable, FDA-standard pain relief, allergy, cold and flu, digestive health and other treatments, manufactured by or for Perrigo Company and sold as store-brand alternatives to leading national brands.

Starts at $5.49